Diet-induced obesity decreases liver iron stores in mice fed iron deficient, adequate, or excessive diets
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چکیده
Diet-induced Obesity Decreases Liver Iron Stores in Mice Fed Iron Deficient, Adequate, or Excessive Diets
منابع مشابه
Duodenal mucosal reductase in wild-type and Hfe knockout mice on iron adequate, iron deficient, and iron rich feeding.
BACKGROUND Genetic haemochromatosis is a common hereditary iron loading disorder in humans. The disease is associated with loss of function mutations in the HFE gene. This is thought to change iron stores via increased iron absorption. AIMS In this study we investigated how adaptation of mucosal reductase activity is engaged in this process and how the changes compare with adaptation seen whe...
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Several oxidative stressors (dietary selenium deficiency, dietary vitamin E deficiency coupled with fish oil feeding, genetic reduction of glutathione peroxidase activity) allow a normally benign coxsackievirus B3 (CVB3/0) to damage heart muscle in host mice. This study investigated whether dietary iron overload, another oxidant stress, would also permit CVB3/0 to exert a cardiopathologic effec...
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Iron deficiency (DO) markedly decreases the concentration of iron and calcium in the liver, femur and sternum. We investigated the effect of the source of dietary iron [ferric citrate alone (citrate diet), or combined with bovine blood at a proportion of 1: 1 (citrate+heme diet), and ferric protein (protein-Fe diet)] on the nutritive utilization of Fe, Ca, P and Mg in anemic and healthy rats. A...
متن کاملThe potentiating and protective effects of ascorbate on oxidative stress depend upon the concentration of dietary iron fed C3H mice.
Ascorbic acid (AA) is an antioxidant that, in the presence of iron and hydrogen peroxide, increases the production of hydroxyl radicals in vitro. Whether AA has similar pro-oxidant properties in vivo may depend upon the relative balance of iron and AA concentrations. In this study, C3H mice were fed diets supplemented with 100 or 300 mg/kg iron, with or without AA (15 g/kg), for 12 months. Live...
متن کاملA corn oil-based diet protects against combined ethanol and iron-induced liver injury in a mouse model of hemochromatosis.
BACKGROUND Combined iron overload and alcohol may promote synergistic chronic liver injury and toxicity. The role of specific dietary fats in influencing the development of co-toxic alcoholic liver disease needs further evaluation and is investigated in this study. METHODS Wild-type (WT) and the iron-loaded Hfe-null (Hfe(-/-) ) mice were fed chow (CC), a AIN-93G standard control (SC), or a co...
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تاریخ انتشار 2016